Protein Structure and Modeling

<p>CHAPTER 1 - Protein Structure <br></p><p>1.1 Polypeptide chain</p><p>1.2 Ligand binding </p><p>1.3 Active site</p><p>1.3 Structure-function</p><p><br></p><p>CHAPTER 2 - Conformational transitions</p><p>2.1 Types of transitions in molecular systems</p><p>2.2 Conformational states</p><p>2.3 Quantum motions</p><p>2.4 Myoglobin and hemoglobin</p><p>2.5 Cytochromes</p><p>2.6 Tobacco mosaic virus coat protein</p><p>2.7 Fibrin-fibrinogen</p><p>2.8 Conformational changes of side chains in protein interior as a basis of the conformational states of the molecule</p><p><br></p><p>CHAPTER 3 – Allosteric regulation</p><p>3.1 Proteins</p><p>3.2 Nucleic acids</p><p>3.3 Small ligands</p><p><br></p><p>CHAPTER 4 – Protein channels</p><p>4.1 Structure-function</p><p>4.2 Signaling &nbsp; &nbsp; &nbsp;&nbsp;</p><p><br></p><p>CHAPTER 5 - Helical assemblies</p><p>5.1 Determinants of specific helix recognition</p><p>5.2 Types of assemblies</p><br><p></p><p>CHAPTER 6 - multiprotein complexes</p><p>6.1 Postsynaptic density</p><p>6.2 Viruses</p><p>6.3 Implications in signaling</p><p><br></p><p>CHAPTER 7 - Methods of structure determination</p><p>7.1 X-Ray crystallography, NMR and Electron Microscopy</p><p>7.2 NMR</p><p>7.3 Electron Microscopy</p><p><br></p><p>CHAPTER 8 – Protein modeling</p><p>8.1 Helix and its interactions</p><p>8.2 Ligands</p><p>8.3 Dynamics</p><p><br></p><p>References</p><p><br></p><p>Dictionary&nbsp;</p><p><br></p>

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