Editor’s remarks: Evolving concepts for local therapies for glioma • Z. Ram, M. Hadani: Intraoperative imaging – MRI • P. C. Warnke: Stereotactic volumetric resection of gliomas • W. Stummer, H.-J. Reulen, A. Novotny, H. Stepp, J.-C. Tonn: Fluorescence-guided resections of malignant gliomas – an overview • M. Warmuth-Metz: Postoperative imaging after brain tumor resection • C. Nimsky, O. Ganslandt, B. v. Keller, R. Fahlbusch: Preliminary experience in glioma surgery with intraoperative high-field MRI • J. Jääskeläinen, T. Randell: Awake craniotomy in glioma surgery • S. C. Short: External beam and conformal radiotherapy in the management of gliomas • P. C. Warnke, K. Kopitzki, C. B. Ostertag: Interstitial stereotactic radiosurgery • P. Menei, J.-P. Benoit: Implantable drug-releasing biodegradable microspheres for local treatment of brain glioma • J. Jääskeläinen: Non-invasive transcranial High Intensity Focused Ultrasound (HIFUS) under MRI thermometry and guidance in the treatment of brain lesions • M. Westphal, K. Lamszus, D. Hilt: Intracavitary chemotherapy for glioblastoma: present status and future directions • C. Goetz, W. Rachinger, G. Poepperl, M. Decker, F.-J. Gildehaus, S. Stocker, G. Jung, K. Tatsch, J.-C. Tonn, H.-J. Reulen: Intralesional radioimmunotherapy in the treatment of malignant glioma: clinical and experimental findings • M. Ravic: Intracavitary treatment of malignant gliomas: radioimmunotherapy targeting fibronectin • A. Merlo, J. Mueller-Brand, H. R. Maecke: Comparing monoclonal antibodies and small peptidic hormones for local targeting of malignant gliomas • F. W. Weber, F. Floeth, A. Asher, R. Bucholz, M. Berger, M. Prados, S. Chang, J. Bruce, W. Hall, N. G. Rainov, M. Westphal, R. E. Warnick, R. W. Rand, F. Rommel, H. Pan, V. N. Hingorani, R. K. Puri: Local convection enhanced delivery of IL4-Pseudomonas exotoxin (NBI-3001) for treatment of patients with recurrent malignant glioma •S. Kunwar: Convection enhanced delivery of IL13-PE38QQR for treatment of recurrent malignant glioma: presentation of interim findings from ongoing phase 1 studies • N. G. Rainov, H. Ren: Oncolytic viruses for treatment of malignant brain tumours • W. Hamel, M. Westphal: Gene therapy of gliomas • R. Bjerkvig, T.-A. Read, P. Vajkoczy, P. Aebischer, W. Pralong, S. Platt, J. E. Melvik, A. Hagen, M. Dornish: Cell therapy using encapsulated cells producing endostatin • M. Kirsch, O. Heese, M. Westphal, G. Schackert: Stem cells in neuro-oncology – development, regeneration and treatment • A. Giese: Glioma invasion – Pattern of dissemination by mechanisms of invasion and surgical intervention, pattern of gene expression and its regulatory control by tumorsuppressor p53 and proto-oncogene ETS-1 • J. C. Tonn, R. Goldbrunner: Mechanisms of glioma cell invasion • K. Lamszus, P. Kunkel, M. Westphal: Invasion as limitation to anti-angiogenic glioma therapy Author Index • Index of Keywords