1. Introduction: interdisciplinary approaches to classic questions about the mind John Cacioppo, Louis G. Tassinary and Gary G. Berntson; Section I. Foundations of Psychophysiology: Part I. Central Nervous System: 2. Elements of functional neuroimaging Tor Wager, Luis Hernandez, John Jonides and Martin Lindquist; 3. Electroencephalography and high density electrophysiological source localization Diego Pizzagalli; 4. Event-related brain potentials: methods, theory, and applications Monica Fabiani, Gabrielle Gratton and Kara Federmeier; 5. Application of transcranial magnetic stimulation (TMS) in psychophysiology Bruce Luber, A. Peterchev, T. Nguyen, A. Sporn and Sarah H. Lisanby; 6. The lesion method in cognitive neuroscience Michael Koenigs, Dan Tranel and Antonio R. Damasio; Part II. Autonomic and Somatic Nervous System: 7. The electrodermal system Mike Dawson and Diane Schell; 8. Cardiovascular psychophysiology Gary G. Berntson, Karen Quigley and Dave Lozano; 9. Gastrointestinal response Robert Stern, Max Levine, Kenneth Koch and Eric Muth; 10. The respiratory system Tyler Lorig; 11. The sexual response Eric Jannsen, Nicole Prause and James Geer; 12. The skeletomotor system: surface electromyography Louis G. Tassinary, John T. Cacioppo and Eric J. Vanman; Part III. Cellular and Humoral Systems: 13. The neuroendocrinology of stress George Chrousos and Gregory Kaltsas; 14. Reproductive hormones Charles Snowdon and Toni Ziegler; 15. Innate and cell-mediated immunity: basic principles and psychophysiological influences Firdaus Dhabhar; 16. Psychosocial effects on humoral immunity: neural and neuroendocrine mechanisms Virginia Sanders, Nicholas Kin and Georg Ponatz; Section II. Elements and Principles: Part IV. Thematic Psychophysiology: 17. Behavioral genetics A. Courtney DeVries and Randy Nelson; 18. Probing the mechanisms of attention Michael Posner, M. Rosario Rueda and Philipp Kansk; 19. Integrative physiology: homeostasis, allostasis and the orchestration of systemic physiology Gary G. Berntson and John Cacioppo; 20. Developmental psychophysiology: conceptual and methodological issues Nathan Fox, Louis A. Schmidt, Heather A. Henderson and Peter Marshall; 21. Interoception Barry Dworkin; 22. The anatomy and physiology of the motor system in humans Ana Solodkin, Petr Hlustik and Giovanni Buccino; 23. The neural basis of affective and social behavior Ralph Adolphs and Michael Spezio; 24. Language Marta Kutas, Kara Federmeier, Jenny Staab and Robert Kluender; 25. Emotion and motivation Margaret M. Bradley and Peter Lang; 26. Stress and illness Timothy Smith, Bert Uchino, Julianne Holt-Lunstad, Rebecca Campo and Maija Reblin; 27. Sleep and dreaming Terry Pivik; Part V. Applications: 28. Psychophysiology in research on psychopathology Greg Miller, J. Christopher Edgar, Jennifer Keller and Wendy Heller; 29. Detection of deception William Iacono; 30. Neuroergonomics: applications of neuroscience to human factors Arthur Kramer and Raja Parasuraman; 31. Psychophysiological contributions to behavioral medicine and psychosomatics Andrew Steptoe; 32. Environmental psychophysiology Russ Parsons; Part VI. Experimental Design, Data Representation, and Data Analysis Issues: 33. Psychometrics Michael Strube and Laurel Newman; 34. Methodology Richard Jennings and Peter Gianaros; 35. Biosignal processing Gabriele Gratton; 36. Data storage formats in neuroimaging: background and tutorial John Herrington, Bradley Sutton and Gregory Miller.