New Opioid Receptor Modulators and Agonists

The Opioid Receptor System and Novel Aspects of Opioid Pharmacology<br>1. Making Sense of the Complexities of Opioid Receptor Function: Evolving Appreciation of Opioid Receptor Classification and Basic Characteristics<br>2. Allostery at Opioid Receptors: Modulation with Small Molecule Ligands, Regulator of G-Protein Signaling (RGS) Protein Modulation of Opioid Receptor Signaling as a Potential Target for Pain Management<br>3. Opioid Agonist and Antagonist Pharmacology: Phenylpiperidines, Tramadol, Buprenoprhine, Methadone, and Codeine Derivatives Synthetic Opioid Clinical Considerations<br>4. Pharmacogenomics/Precision Medicine: Opioid-related Interactions and Metabolism Considerations<br>5. Opioid-associated Syndromes and Comorbidities<br>6. Opioid-induced Hyperalgesia<br>7. Drug Facts: Novel Synthetic Opioids Synthetic Opioid Misuse and Pain Management<br>8. Roots of the Opioid Crisis: Description of the Four Waves of the Opioid Epidemic<br>9. Opioids and Risk of Dependency: Neurobiology of Opioid Use Disorder<br>10. Opioids and Risk of Dependency: Responsibilities of Healthcare Workers, Manufacturers, and Pharmacists<br>11. CDC Guidelines for Chronic Pain in the Adult, Including Newer Guidelines Against Co-prescription with Benzodiazepines.<br>12. Commonly Prescribed Opioids and Adjuvants in Acute and Chronic Pain Management<br>13. Clinical Considerations of Commonly Prescribed Medications in Substance Abuse Management (e.g., buprenorphine (how is it prescribed); methadone (concerns over prolonged QT EKG prior to administration; urine drug screens<br>14. The Role of Naltrexone and Novel Preparations for Substance Abuse and Pain Management<br>15. Palliative Care for Cancer and Considerations for Opioid-mediated Suppression of Natural Killer Cells<br>16. Abuse Deterrent Formulations of Opioids and Opioid Vaccines<br>17. Opioid Detoxification Techniques