Structure and Intrinsic Disorder in Enzymology

<p>1. Enzymology: Early insights<br>2. Deep mutational scanning to probe specificity determinants.<br>3. Protein flexibility and cryo-enzymology: The trade-off between stability andcatalytic rates<br>4. Thermodynamic Perspective of Protein Disorder and Phase Separation: Model Systems<br>5. Structure and disorder: Protein functions depend on this new binary transforming lock-and-key into structure-function continuum<br>6. Methods for measuring structural disorder in proteins<br>7. Prediction of protein structure and intrinsic disorder in the era of deep learning<br>8. Roles of Intrinsically Disordered Regions in Phosphoinositide 3-Kinase Biocatalysis<br>9. Many faces of protein promiscuity: Not just broad specificity of proteins<br>10. Role Of Plasticity And Disorder In Protein Moonlighting: Blurring Of Lines Between Biocatalysts And Other Biologically Active Proteins<br>11. Molten globular enzymes<br>12. Intrinsic disorder and allosteric regulation<br>13. Macromolecular Crowding: How it Affects Protein Structure, Disorder, and Catalysis<br>14. Intrinsic disorder and post-translational modifications: An evolutionary perspective<br>15. The roles of prion-like domains in amyloid formation, phase separation, and solubility<br>16. IDPRs of membrane proteins influence membrane curvature<br>17. How binding to surfaces affects disorder</p>