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Hematology

Basic Principles and Practice

Specificaties
Gebonden, blz. | Engels
Elsevier Health Sciences | 2022
ISBN13: 9780323733885
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Elsevier Health Sciences e druk, 2022 9780323733885
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Extensively revised, comprehensive content from leading global contributors ensures that Hematology, 8th Edition, remains your #1 choice for expert guidance in all areas of this rapidly advancing subspecialty. This edition reflects the numerous advances that are redefining the field and dramatically influencing new approaches to diagnosis, treatment, and outcomes. Well-illustrated and clinically focused, it details the basic science and clinical practice of hematology and hematopoietic cellular therapy—covering virtually all aspects of hematology in one definitive resource.

Covers all hematologic disorders, including comprehensive discussions of hematologic malignancies, individualized patient care, cell-based therapies, transplantation, transfusion medicine, hemostasis, thrombosis, and consultative hematology—in one convenient volume.

Provides state-of-the-art guidance from global experts at the forefront of the latest research and clinical practice.

Provides extensive updates throughout on basic science research, advances in molecular diagnostics, new drugs, immunotherapies, personalized medicine, laboratory medicine, transfusion medicine, stem cell transplantation, and clinical treatment for all hematologic malignancies and non-malignancies

Contains new chapters on gene editing; the impact of mitochondria on hematopoiesis; myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes; immunotherapy and management of its toxicities; transfusion medicine in sickle cell disease; principles of radiation therapy; and COVID-19, including complications of vaccination and its impact on the hematologic system.

Discusses many new advances in the field, including details and the future of gene therapy for hemophilia, gene editing for sickle cell disease and thalassemia, the evolution of cellular therapy, use of cells, transfusion medicine vs. protein therapy, gene sequencing, immunotherapy, and new targeted drugs.

Includes more decision-making algorithms for formulating diagnoses and personalized treatment plans for those highly complex disorders that require individualized approaches.

Addresses the effects of aging on hematopoiesis and on the manifestations of a variety of hematologic disorders.

Discusses cardio-oncology and its impact on the treatment of patients with hematologic disorders.

Presents relevant basic science as background for clinical application in later sections.

An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

Specificaties

ISBN13:9780323733885
Taal:Engels
Bindwijze:Gebonden

Inhoudsopgave

PART I MOLECULAR AND CELLULAR BASIS OF HEMATOLOGY<br>1. Anatomy and Physiology of the Gene<br>2. Epigenomics in Hematology<br>3. Genomic Approaches to Hematology<br>4. Regulation of Gene Expression in Hematology<br>5. Genome Editing<br>6. Signaling Transduction and Metabolomics<br>7. Protein Architecture: Relationship of Form and Function<br>8. Pharmacogenomics and Hematologic Diseases<br>PART II CELLULAR BASIS OF HEMATOLOGY<br>9. Hematopoietic Stem Cell Biology<br>10. Mitochondria and Hematopoiesis<br>11. Cytokines, Chemokines, Other Growth Factors, and Their Receptors<br>12. Role of Chemokines in Leukocyte Trafficking<br>13. Stem Cell Model of Hematologic Diseases<br>14. Hematopoietic Microenvironment<br>15. Cell Adhesion<br>16. Current Biology of Stem Cell Homing and Mobilization: Dynamic Interactions Between Hematopoietic Stem and Progenitor Cells and Their Surrounding Bone Marrow Microenvironment<br>17. Control of Cell Division<br>18. Cell Death<br>19. Aging and Hematopoiesis<br>PART III IMMUNOLOGIC BASIS OF HEMATOLOGY<br>20. Dendritic Cell Biology<br>21. Natural Killer Cell Immunity and Therapy<br>22. B-Cell Development<br>23. Complement and Immunoglobulin Biology Leading to Clinical Translation<br>24. T-Cell Immunity<br>25. Unmodified Ex Vivo Expanded T Cells<br>26. Treatment of Hematologic Malignancies with Genetically Modified T Cells<br>PART IV DISORDERS OF HEMATOPOIETIC CELL DEVELOPMENT<br>27. Biology of Erythropoiesis, Erythroid Differentiation, and Maturation<br>28. Granulocytopoiesis and Monocytopoiesis<br>29. Thrombocytopoiesis<br>30. Inherited Bone Marrow Failure Syndromes<br>31. Aplastic Anemia<br>32. Paroxysmal Nocturnal Hemoglobinuria<br>33. Acquired Disorders of Red Cell, White Cell, and Platelet Production<br>PART V RED BLOOD CELLS<br>34. Pathobiology of the Human Erythrocyte and Its Hemoglobins<br>35. Approach to Anemia in the Adult and Child<br>36. Iron Homeostasis and Its Disorders<br>37. Disorders of Iron Homeostasis: Iron Deficiency and Overload<br>38. Anemia of Chronic Inflammation<br>39. Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias<br>40. Megaloblastic Anemias<br>41. Thalassemia Syndromes<br>42. Pathobiology of Sickle Cell Disease<br>43. Clinical Aspects of Sickle Cell Disease<br>44. Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias<br>45. Red Blood Cell Enzymopathies<br>46. Red Blood Cell Membrane Disorders<br>47. Autoimmune Hemolytic Anemia<br>48. Extrinsic Nonimmune Hemolytic Anemias<br>PART VI NON-MALIGNANT LEUKOCYTES<br>49. Neutrophilic Leukocytosis, Neutropenia, Monocytosis, and Monocytopenia<br>50. Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia, and Hypogammaglobulinemia<br>51. Disorders of Phagocyte Function<br>52. Congenital Disorders of Lymphocyte Function<br>53. Pediatric and Adult Histiocytic Disorders<br>54. Lysosomal Storage Diseases, Focusing on Gaucher Disease: Perspectives and Principles<br>55. Epstein-Barr Virus and Associated Lymphoproliferative Conditions<br>PART VII HEMATOLOGIC MALIGNANCIES<br>56. Progress in the Classification of Hematopoietic and Lymphoid Neoplasms: Clinical Implications<br>57. Conventional and Molecular Cytogenomic Basis of Hematologic Malignancies<br>58. Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies<br>59. Pathobiology of Acute Myeloid Leukemia<br>60. Clinical Manifestations and Treatment of Acute Myeloid Leukemia<br>61. Myelodysplastic Syndromes<br>62. Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults<br>63. Acute Myeloid Leukemia in Children<br>64. Blastic Plasmacytoid Dendritic Cell Neoplasm<br>65. Myelodysplastic Syndromes and Myeloproliferative Neoplasms in Children<br>66. Pathobiology of Acute Lymphoblastic Leukemia<br>67. Clinical Manifestations and Treatment of Childhood Acute Lymphoblastic Leukemia<br>68. Acute Lymphoblastic Leukemia in Adults<br>69. Chronic Myeloid Leukemia<br>70. The Polycythemias<br>71. Essential Thrombocythemia<br>72. Primary Myelofibrosis and Chronic Neutrophilic Leukemia<br>73. Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes<br>74. Eosinophilia, Eosinophilic Neoplasms, and the Hypereosinophilic Syndromes<br>75. Mast Cells and Mastocytosis<br>76. Chronic Lymphocytic Leukemia<br>77. Hairy Cell Leukemia<br>78. The Pathologic Basis for the Classification of Non-Hodgkin and Hodgkin Lymphomas<br>79. Origin of Hodgkin Lymphoma and Therapeutic Targets<br>80. Hodgkin Lymphoma<br>81. Origin of Non-Hodgkin Lymphoma and Therapeutic Targets<br>82. Clinical Manifestations, Staging, and Treatment of Follicular Lymphoma<br>83. Marginal Zone Lymphomas (Extranodal/MALT, Splenic, and Nodal)<br>84. Diffuse Large B-Cell Lymphoma of the Central Nervous System<br>85. High-Grade B-Cell Lymphomas<br>86. Mantle Cell Lymphoma<br>87. Virus-Associated Lymphoma<br>88. Malignant Lymphomas in Childhood<br>89. T-Cell Lymphomas<br>90. Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma<br>91. Multiple Myeloma<br>92. Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma<br>93. Immunoglobulin Light-Chain Amyloidosis (Primary Amyloidosis)<br>PART VIII COMPREHENSIVE CARE OF PATIENTS WITH HEMATOLOGIC MALIGNANCIES<br>94. Key Considerations for Managing Infections in the Compromised Host<br>95. Principles of Radiation Therapy for Hematologic Disease<br>96. Grading and Toxicity Management after Immune Effector Therapy<br>97. Identification and Management of Checkpoint Inhibition Toxicity<br>98. Psychosocial Aspects of Hematologic Disorders<br>99. Pain Management and Antiemetic Therapy in Hematologic Disorders<br>100. Palliative Care<br>101. Therapy-related Late Effects of Hematologic Malignancies<br>PART IX TRANSPLANTATION AND OTHER CELL-BASED THERAPIES<br>102. Practical Aspects of Hematopoietic Stem Cell Harvesting and Mobilization<br>103. Graft Engineering and Cell Processing<br>104. Principles of Cell-Based Genetic Therapies<br>105. Indications, Outcomes, and Donor Selection for Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies in Adults<br>106. Unrelated Donor Hematopoietic Cell Transplantation<br>107. Haploidentical Hematopoietic Stem Cell Transplantation<br>108. Cord Blood Transplantation<br>109. Graft-versus-Host Disease and Graft-versus- Leukemia Responses<br>110. Supportive Care for the Transplant Patient<br>PART X TRANSFUSION MEDICINE<br>111. Human Blood Group Antigens and Antibodies<br>112. Principles of Red Blood Cell Transfusion<br>113. Clinical Considerations in Platelet Transfusion Therapy<br>114. Human Leukocyte Antigen and Human Neutrophil Antigen Systems<br>115. Principles of Plasma and Plasma Derivatives<br>116. Hemapheresis<br>117. Transfusion Reactions to Blood and Hematopoietic Stem Cell Therapy Products<br>118. Transfusion-Transmitted Diseases<br>119. Pediatric Transfusion Medicine<br>120. Transfusion and Apheresis Support for Sickle Cell Disease Patients<br>PART XI HEMOSTASIS AND THROMBOSIS<br>121. Overview of Hemostasis and Thrombosis<br>122. Blood Vessels<br>123. Megakaryocyte and Platelet Structure<br>124. Molecular Basis of Platelet Function<br>125. Molecular Basis of Blood Coagulation<br>126. Evaluation of the Patient with Suspected Bleeding Disorders<br>127. Laboratory Evaluation of Hemostatic and Thrombotic Disorders<br>128. Acquired Disorders of Platelet Function<br>129. Diseases of Platelet Number: Immune Thrombocytopenia, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura<br>130. Thrombocytopenia Caused by Hypersplenism, Platelet Destruction, or Surgery/Hemodilution<br>131. Heparin-Induced Thrombocytopenia<br>132. Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndromes<br>133. Structure, Biology, and Genetics of von Willebrand Factor<br>134. Hemophilia A and B<br>135. Rare Coagulation Factor Deficiencies<br>136. Transfusion Therapy for Coagulation Factor Deficiencies<br>137. Disseminated Intravascular Coagulation<br>138. Hypercoagulable States<br>139. Antiphospholipid Syndrome<br>140. Venous Thromboembolism<br>141. Prevention and Treatment of Venous Thromboembolism in Pregnancy<br>142. Atherothrombosis<br>143. Antithrombotic Drugs<br>144. Stroke<br>145. Acute Coronary Syndromes<br>146. Peripheral Artery Disease<br>147. Atrial Fibrillation<br>148. Bleeding and Clotting Disorders in Pediatrics<br>PART XII CONSULTATIVE HEMATOLOGY<br>149. Hematologic Changes in Pregnancy<br>150. Hematologic Manifestations of End-Organ Failure<br>151. Hematologic Manifestations of Solid Tumors<br>152. Hematologic Manifestations of HIV/AIDS<br>153. Hematologic Findings and Consequences of Novel Coronavirus (SARS-CoV-2) Infection<br>154. Hematologic Aspects of Parasitic Diseases<br>155. Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis<br>156. The Spleen and Its Disorders<br>157. Aging and Hematologic Disorders<br>158. Onco-cardiology: Focus on Cardiac Complications of Hematologic Treatments<br>159. Resources for the Hematologist: Interpretive Comments and Selected Reference Values for Neonatal, Pediatric, and Adult Populations 2408.e1<br>Chapter 159 can be found online at Elsevier eBooks for Practicing Clinicians<br>Index
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