Ion Channels and Their Inhibitors

Specificaties
Gebonden, 348 blz. | Engels
Springer Berlin Heidelberg | 2011e druk, 2011
ISBN13: 9783642199219
Rubricering
Springer Berlin Heidelberg 2011e druk, 2011 9783642199219
€ 120,99
Levertijd ongeveer 9 werkdagen
Gratis verzonden

Samenvatting

Being the crucial components of living cells, ion channels are important targets of therapeutic agents. Historically, it has been challenging to develop drugs on this target class. A major issue with target based ion channel drug development is the identification of effective small chemical leads for medicinal chemistry optimization to the clinical candidate status. Thus enough attention has been paid to the study of structure and functions of ion channels and their potential inhibitors. The present book compiles important chapters authored by eminent workers in the field to cover important recent advances in the studies of the structure and functions of ion channels and their inhibitors, such as sodium ion, potassium ion, chloride ion, calcium ion channel inhibitors. The book may be of great use to the students and scientists working in the area of molecular biology, biochemistry, physiology, neurobiology, and medicinal chemistry.

Specificaties

ISBN13:9783642199219
Taal:Engels
Bindwijze:gebonden
Aantal pagina's:348
Uitgever:Springer Berlin Heidelberg
Druk:2011

Inhoudsopgave

<p>Structural and Functional Discrimination of Membrane.- Proteins.- Pharmacology of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels.- Advanced Molecular Modeling Techniques Applied to Ion Channels Blockers.- Advances in Design and Development of Sodium Channel Blockers.- Potassium Channel Blockers as Anti-arrhythmic Agents.-  hERG Potassium Channels in Drug Discovery and Development.- Prediction of hERG Channel Inhibition Using in silico Techniques.- Advances in Structure-Activity Relationship Studies on Potassium Channel Modulators.- </p><p>Calcium Ion Channels and Their Blockers.- Therapeutic Potential of N-type Voltage Gated Ca<sup>2+ </sup>Channel.- Chloride Ion Channels: Structure, Functions, and Blockers.</p>
€ 120,99
Levertijd ongeveer 9 werkdagen
Gratis verzonden

Rubrieken

    Personen

      Trefwoorden

        Ion Channels and Their Inhibitors