Sudhir Gupta,
Frederick W. Alt,
Max D. Cooper,
Fritz Melchers,
Klaus Rajewsky
e.a.
Springer US
2007e druk, 2007
9780387465272
Mechanisms of Lymphocyte Activation and Immune Regulation XI
B Cell Biology
Specificaties
Gebonden, 198 blz.
|
Engels
Springer US |
2007e druk, 2007
ISBN13: 9780387465272
Rubricering
Onderdeel van serie
Advances in Experimental Medicine and Biology
Levertijd ongeveer 9 werkdagen
Gratis verzonden
Samenvatting
In recent years, major developments have increased understanding of various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.
Specificaties
ISBN13:9780387465272
Taal:Engels
Bindwijze:gebonden
Aantal pagina's:198
Uitgever:Springer US
Druk:2007
Inhoudsopgave
Regulation and Function of the E2A Proteins in B Cell Development.- Multiple Roles for Blimp-1 in B and T Lymphocytes.- Memory B Cell Evolution: B Cell Biology.- BCR-linked Factors in Developmental Fate Decisions.- Gene Regulatory Networks that Orchestrate the Development of B Lymphocyte Precursors.- Rules for the Rearrangement Events at the L Chain Gene Loci of the Mouse.- Regulation of AID Function In Vivo.- Targeting of AID to Immunoglobulin Genes.- Targeting AID to the Ig Genes.- DNA Replication to Aid Somatic Hypermutation.- Regulation of Activation Induced Deaminase via Phosphorylation.- Modulation of MHC Class II Signal Transduction by CD19.- Role of NFUP?B Signaling in Normal and Malignant B Cell Development.- Fc Receptor–like Proteins (FCRL): Immunomodulators of B Cell Function.- Tolerance Mechanisms in the Late Phase of the Antibody Response.- Role of RS/?DE in B Cell Receptor Editing.- The Regulation of Receptor Editing.- B Cell Hyporesponsiveness and Autoimmunity: A New Paradigm.