Mitochondrial Intoxication

Specificaties
Paperback, blz. | Engels
Elsevier Science | 2022
ISBN13: 9780323884624
Rubricering
Elsevier Science e druk, 2022 9780323884624
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Samenvatting

Mitochondrial Intoxication explores the effects toxic molecules can have upon mitochondrial physiology in the human body. Each chapter is dedicated to a specific toxicant, including pollutants, food additives, illicit and pharmaceutical drugs, and heavy metals. This book considers the implications and impact these have upon mitochondria and the diseases that can result from dysfunction and impairment in the human body. Furthermore, the book provides an overview of mitochondrial physiology and assesses the advances and challenges in testing mitochondrial toxicity. Case studies exploring mitochondrial intoxication in pregnancy and in the geriatric population are also included.

This is a comprehensive reference on the main toxicants impacting mitochondria in the human body, and the consequences this can have for health and disease.

Specificaties

ISBN13:9780323884624
Taal:Engels
Bindwijze:Paperback

Inhoudsopgave

1. Mitochondrial physiology: An overview<br>2. Molecular markers of mitochondrial intoxication <br>3. Drug-induced mitochondrial impairment: Mechanisms and testing systems <br>4. Challenges in mitochondrial profiling during pre-clinical studies <br>5. Acrylamide <br>6. The effects of air pollution toxicants on the mitochondria <br>7. Aflatoxin B <br>8. The effects of the alcohol abuse against the mitochondria. Functional consequences for liver, muscle, and the brain <br>9. Aluminum <br>10. Discovery of amiodarone mitochondrial toxicity in liver and beyond <br>11. Ammonia <br>12. The mitochondrial disruption as a contributing factor for the neurotoxicity of amphetamines <br>13. Anthracycline <br>14. Antidepressants, mood stabilizing drugs and mitochondrial function; for better or for worse <br>15. The effects of antiretroviral drugs on the mitochondria <br>16. Arsenic <br>17. Mechanisms of bisphenol A toxicity in mitochondria <br>18. Chemotherapeutic drugs <br>19. Cuprizone <br>20. Delta‐9‐tetrahydrocannabinol (Cannabis sativa) <br>21. Diclofenac <br>22. Food additives <br>23. Mitochondria as a toxicological target for fungicides <br>24. The effects of methylglyoxal on the mitochondria <br>25. The effects of mercury on the mitochondria <br>26. Organohalogens <br>27. The effects of organophosphate pesticides on the mitochondria <br>28. Oxygen toxicity <br>29. Paracetamol/Acetaminophen <br>30. Plant molecules (Mitochondrial intoxication induced by plant molecules) <br>31. Polychlorinated biphenyls (PCBs) <br>32. The effects of polycyclic aromatic hydrocarbons on the mitochondria <br>33. Pyrethroids <br>34. Redox cycling compounds (Mitochondrial toxicity of redox cycling compounds) <br>35. The effects of sodium nitrate on the mitochondria <br>36. Zinc
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