<p>Volume 1<br>Part I: Basic principles<br>Section A Cell biology<br>1. Molecular and cellular regulation of intramembranous and endochondral bone formation during embryogenesis<br>2. Skeletal stem cells: tissue-specific stem/progenitor cells of cartilage, bone, stroma, and marrow adipocytes<br>3. Bone marrow and the hematopoietic stem cell niche<br>4. The osteoblast lineage: its actions and communication mechanisms<br>5. Osteoclasts<br>6. The osteocyte<br>7. Transcriptional control of osteoblast differentiation and function<br>8. Wnt signaling and bone cell activity<br>9. Vascular and nerve interactions<br>10. Coupling of bone formation and resorption<br>11. Modeling and remodeling: the cellular machinery responsible for bone’s material and structural strength during growth, aging, and drug therapy<br>12. Aging and bone</p> <p>Section B Biochemistry<br>13. Type I collagen structure, synthesis, and regulation<br>14. Collagen cross-linking and bone pathobiology<br>15. Secreted noncollagenous proteins of bone<br>16. Bone proteinases<br>17. Integrins and other cell surface attachment molecules of bone cells<br>18. Intercellular junctions and cellecell communication in the skeletal system</p> <p>Section C Bone remodeling and mineral homeostasis<br>19. Histomorphometric analysis of bone remodeling<br>20. Phosphorus homeostasis and related disorders<br>21. Magnesium homeostasis<br>22. Metal ion toxicity in the skeleton: lead and aluminum<br>23. Biology of the extracellular calcium-sensing receptor</p> <p>Section D Endocrine and paracrine regulation of bone<br>24. Parathyroid hormone molecular biology<br>25. Paracrine parathyroid hormonee related protein in bone: physiology and pharmacology<br>26. Cardiovascular actions of parathyroid hormone/parathyroid hormoneerelated protein signaling<br>27. Parathyroid hormone and parathyroid hormoneerelated protein actions on bone and kidney<br>28. Receptors for parathyroid hormone and parathyroid hormoneerelated protein<br>29. Structure and function of the vitamin D-binding proteins<br>30. Vitamin D gene regulation<br>31. Nonskeletal effects of vitamin D: current status and potential paths forward<br>32. Cellular actions of parathyroid hormone on bone<br>33. Calcitonin peptides<br>34. Regulation of bone remodeling by central and peripheral nervous signals</p> <p>Section E Other systemic hormones that influence bone metabolism<br>35. Estrogens and progestins<br>36. Physiological actions of parathyroid hormone-related protein in epidermal, mammary, reproductive, and pancreatic tissues<br>37. The pharmacology of selective estrogen receptor modulators: past and present<br>38. Thyroid hormone and bone<br>39. Basic and clinical aspects of glucocorticoid action in bone<br>40. Diabetes and bone<br>41. Androgen receptor expression and steroid action in bone</p> <p>Section F Local regulators<br>42. Growth hormone, insulin-like growth factors, and IGF binding proteins</p> <p>Volume 2<br>43. The periodontium<br>44. Notch and its ligands<br>45. Fibroblast growth factor (FGF) and FGF receptor families in bone<br>46. Vascular endothelial growth factor and boneevascular interactions<br>47. Transforming growth factor-b and skeletal homeostasis<br>48. Bone morphogenetic proteins<br>49. Extraskeletal effects of RANK ligand<br>50. Local regulators of bone<br>51. Prostaglandins and bone metabolism</p> <p>Part II: Molecular mechanisms of metabolic bone disease<br>52. The molecular actions of parathyroid hormone/parathyroid hormoneerelated protein receptor type 1 and their implications<br>53. Multiple endocrine neoplasia type 1<br>54. Parathyroid hormone-related peptide and other mediators of skeletal manifestations of malignancy<br>55. Localized osteolysis<br>56. Genetic regulation of parathyroid gland development<br>57. Genetic disorders caused by mutations in the parathyroid hormone/parathyroid hormonee related peptide receptor, its ligands, and downstream effector molecules<br>58. Molecular basis of parathyroid hormone overexpression<br>59. Diseases resulting from defects in the G protein Gsa<br>60. Renal osteodystrophy and chronic kidney diseaseemineral bone disorder<br>61. Osteogenesis imperfecta<br>62. Hereditary deficiencies in vitamin D action<br>63. Fibroblast growth factor 23<br>64. Tumor-induced osteomalacia<br>65. Osteopetrosis<br>66. Hypophosphatasia: nature’s window on alkaline phosphatase function in humans<br>67. Paget’s disease of bone<br>68. Genetic determinants of bone mass and osteoporotic fracture</p> <p>Part III: Pharmacological mechanisms of therapeutics<br>69. Pharmacologic mechanisms of therapeutics: parathyroid hormone<br>70. Calcium<br>71. Drugs acting on the calcium receptor: calcimimetics and calcilytics<br>72. Clinical and translational pharmacology of bisphosphonates<br>73. Pharmacological mechanisms of therapeutics: receptor activator of nuclear factorekappa B ligand inhibition<br>74. Pharmacologic basis of sclerostin inhibition<br>75. Vitamin D and its analogs<br>76. Mechanisms of exercise effects on bone quantity and quality</p> <p>Part IV: Methods in bone research<br>77. Application of genetically modified animals in bone research<br>78. Bone turnover markers<br>79. Microimaging<br>80. Macroimaging<br>81. Methods in lineage tracing<br>82. Bone histomorphometry in rodents<br>83. Bone strength testing in rodents<br>84. Regulation of energy metabolism by bone-derived hormones</p>
